DNA evolution models made invaluable contributions to comparative genomics, although it seemed formidable to include non-genomic features into these models.In order to build an evolutionary model of transcription networks (TNs), we had to forfeit the substitution model used in DNA evolution and to start from modeling the evolution of the regulatory

The DMPTool NIH Data Management and Sharing Plan (DMSP) Templates Project was launched in response to the 2023 NIH Data Management and Sharing (DMS) Policy.This new policy introduced a more structured framework for DMS Plans, featuring six key elements, a departure from the 2003 NIH DMS policy.The project aimed to simplify the process for data rat

BackgroundThe mechanisms of epigenetic regulation emerge as a fundamental determinant in the complex landscape of cancer initiation and advancement.However, the specific impact of epigenetic regulation on cancer progression remains unclear.To explore the relationship between epigenetic regulation and cancer progression, we utilized transcriptomic d